Broad spectrum anthelmintic resistance of Haemonchus contortus in Northern NSW of Australia

 

Short communication
Broad spectrum anthelmintic resistance of Haemonchus contortus in Northern NSW of Australia
Jane Lamb, Tim Elliott, Michael Chambers, Bruce Chick

https://www.researchgate.net/publication/316945254_Broad_Spectrum_Anthelmintic_Resistance_of_Haemonchus_Contortus_in_Northern_NSW_of_Australia [accessed Jul 12 2018].    Vet Parasitol 241 (2017) 48-51

https://www.researchgate.net/deref/http%3A%2F%2Fdx.doi.org%2F10.1016%2Fj.vetpar.2017.05.008

Abstract
On a sheep farm in Northern New South Wales (NSW) of Australia a degree of anthelmintic resistance was suspected. With noticeable clinical signs of infection and sheep not responding to treatment, a faecal egg count reduction test was conducted to ascertain the broad spectrum of anthelmintic resistance at this farm. A number of classes of anthelmintics were assessed including organophosphate, macrocyclic lactone (ML) and in combination an ML, benzimidazole, levamisole and salicylanilide. In addition, the more recently registered classes of anthelmintics, monepantel (amino-acetonitrile derivative) and derquantel/abamectin combination (spiroindole + ML) were included.
Ninety merino sheep naturally infected with a field strain of Haemonchus contortus were randomly allocated to 6 treatment groups (15 animals/group). Sheep were subsequently treated based on label recommendations and individual bodyweight. Faecal samples were collected post-treatment on Days 7, 14 and 21 to conduct faecal egg
counts and group bulk larval cultures.
Broad spectrum anthelmintic resistance was confirmed at this site with treatment efficacies ranging from 21.3% (monepantel) to 93.8% (derquantel/abamectin combination) against the H. contortus strain. Furthermore, resistance to the multi-combination anthelmintic containing 4 active ingredients was evident (52.5%). This broad spectrum of resistance highlights the need for integration of alternative sustainable methods in parasite control in order to slow development of resistance and increase the life time effectiveness of anthelmintics.
(Emphases (bolding) is mine. – SL)

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How do you respond to this?

Basically the answers for Australian sheep producers are in WormBoss.

Specifically a first priority is to find out which drenches are effective on your property.  Otherwise you are flying in the dark, with no lights.

Another top priority is to get into regular worm egg counting.   Boring and basic stuff, but vitally important.

http://www.wormboss.com.au/tests-tools/tests/checking-for-drench-resistance-with-a-drenchcheck.php

http://www.wormboss.com.au/tests-tools/tests/testing-drench-effectiveness-with-a-drenchtest.php

http://www.wormboss.com.au/tests-tools/tests/worm-egg-counting.php

SL, Armidale.  12 July 2018

(Retiring 13 July 2018 (seriously);… a black day for NSW DPI and NSW livestock industries…(joking!))

 

 

 

 

 

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WormFax – the back story

WormFax NSW is (was) a service to NSW sheep producers and their advisors. It was a summary of WormTest results (in sheep) from around NSW.   I say ‘was’ because I am retiring (13/7/18) and the service will cease, at least for the time being.

The data for WormFax was supplied each month from two NSW-based parasitology labs: the NSW DPI lab at EMAI and a private lab located at Armidale in NSW. This private lab, formerly part of Veterinary Health Research, is now part of Invetus.

I am most grateful to Invetus (Amanda) and EMAI parasitology (Kathy / Angela / Tammy / Emily) for compiling this data each month and sending it to me. They did this for many years. This has been for the public good, not least for the benefit of primary producers and their advisors etc.

Wormfax (or at least notification (via WormMail) that it was available) was distributed to subscribers via email on a monthly basis. The data was posted on NSW DPI’s website: [ https://www.dpi.nsw.gov.au/about-us/publications/wormfax ]. At the time of writing, the WormFax page and data is still there (perhaps of interest for this wanting to do retrospective analyses?).

Background:
The summaries I prepared from the Excel sheets the labs sent me were called ‘WormFax’.  This started way back in the late 1980s early 1990s when I was a veterinary pathologist / research officer at the then Regional Veterinary Laboratory, Armidale (RVL-A) (on the site in UNE where Invetus-Armidale (formerly Veterinary Health Research), is now).
(By the way RVL Armidale, established in the mid 1960s, was the first country-based veterinary laboratory in Australia, if you discount the lab that was at the city of Townsville. The first OIC of RVL-A was Dr A (Alan) R B Jackson).
The OIC of RVL-A at the time (1980s/1990s), Dr Robert Coverdale, was keen to make better use of the parasitology data (‘value adding’) generated by the lab.  (Bob was the OIC after Dr Bruce Chick left the position and went on to work in the private sector, then eventually starting Veterinary Health Research).
And the local Dept. Agric.Veterinary Officer at the time, Dr Marcus Holdsworth, was keen to be involved.   The lab gave Marcus the (de-identified) data each month, and Marcus massaged the data into a monthly newsheet for farmers and advisers. This newsheet contained data summaries and trends and commentary.  The newsheet was sent out by fax initially (computers were just ‘happening’ in a bigger way); hence the name WormFax.   The other labs (e.g. RVL Wagga Wagga) followed suit, with their own versions of WormFax (but none of the other labs produced as much parasitology data as RVL-A. (The New England region of NSW is a hotspot for internal parasites   :-).
What’s been happening:
Using the data the labs supplied, I publicised each monthly edition of WormFax through the WormMail newsletter (email and web), and WormFax was uploaded each month to the WormFax page on the DPI website:  https://www.dpi.nsw.gov.au/about-us/publications/wormfax 
What now:
But, now I am retiring, there is no-one at present to replace me and take on Wormfax and other tasks.
All is not lost, however, as District Veterinarians see (at least some) WormTest results for their districts, and they report each month on what is happening worm-wise in the monthly ParaBoss News.
But to reiterate, I (and others) have very much appreciated Invetus and EMAI parasitology – and you as individuals –  doing this for me, and livestock producers and their advisors and suppliers.
SL
Armidale, 11 July 2018

Vale Dr Boray

Dr J C (Joe) Boray died last Sunday (8th July 2018) after being unwell for a long time.

Many of you would not have known Joe. You would know his name if you are au fait with livestock parasitology, especially liver fluke and associated literature.

At the end of his career, Joe was a research scientist at EMAI. He was a veterinarian and a parasitologist.

He had a stellar career in various organisations and countries. He was one of the people (when he worked for CIBA-GEIGY in Basel) behind ‘Fasinex’ (triclabendazole), the drug of choice for treating liver fluke in animals – and humans.

Joe had a very interesting life, which included escaping from Hungary when it was still under communist rule.  Some of his friends did not make it.

Joe was very generous as well as very knowledgeable. He had a big and positive impact on those who worked with him or otherwise knew him. He was like a father figure for many of us.

As Nick Sangster just said to me in an email:  ” Sad news. The end of an era and an icon”.

More on Joe here if you are interested:

Peter Rolfe informs me  ‘His funeral is on Friday (13/7/18) at Rookwood Cemetery, 2 PM, West Chapel.’

SL

Wed 11 July 2018  Armidale
Addendum 11 July 2018:

Dear Stephen

Thank you for telling me!

Visited dear Joe at his lab with Richard Reinecke.

What a man!!!!!

Please convey my condolences to Joanna.

Father of triclabendazole!!!

What a legacy.

He could breed snails for metacercariae, I was amazed.

Bless you.

Faffa Malan”

Comment from Dr Barry Hosking 12 July:

“Indeed some sad news with Joe Boray’s passing. Faffa summed it nicely, in that Joe was the father of Fasinex (triclabendazole from Ciba-Geigy). Having started my industry career at Ciba 23 years ago I can say that many of my international colleagues would comment if it wasn’t for Joe’s ‘persistence’ with  the company they would never have developed the active ingredient and subsequent products, which have been a godsend for many farmers whose flocks and herds are exposed to liver fluke. Triclabendazole, after more than 30 years of use, is now badly impacted by resistant parasites in some countries but imagine what farming would have been like without it. We clearly have Joe to thank for his foresight in the 1970s on what triclabendazole had to offer.”

 

Comment from Dr Noel Campbell (retired vet. parasitologist), 13 July 2018:

“Hi Steve

Sad to read of Joe’s passing. A wonderful man from whom I learnt so much from. First met Joe in 1967 or 8, I think. 50 years!! I developed my interest in Fluke in the drought years in Armidale in 64-65 and couldn’t have worked on Fluke without Joe’s help. Thanks for publishing his recent overview papers in wormmail. “

WRML.2017-12-08. sundry and various

 

Some recently published worm-related NSW DPI Primefacts:

Other recent:

BioWorma – Duddingtonia references

https://wormmailinthecloud.wordpress.com/2017/12/01/bioworma-duddingtonia-references/

UNE ‘Micro Method’ for doing worm egg counts on bulk faecal samples (sheep, goats etc)

https://wormmailinthecloud.wordpress.com/2017/11/30/une-micro-method-for-doing-worm-egg-counts-on-bulk-faecal-samples-sheep-goats-etc/

 

As intimated previously, WormMail and its editor is taking a break for a few-several months.  🙂 .. Deo volente       Best wishes to you all!

SL    Armidale 2017-12-08T09:30

 

https://xkcd.com/